![]() ![]() individuals were infected with subtype B viruses. All Ugandan patients were infected with non-B HIV-1 subtypes (31% A1, 64% D, or 5% C), while all U.S. Ugandan patients were slightly younger (median age 43 vs 49 years) and had slightly lower CD4 + counts (508 vs 772 cells/ml) than U.S. The peripheral HIV-1 reservoir, i.e., cell-associated HIV-1 RNA and proviral DNA, was characterized using our novel deep sequencing-based EDITS assay. ![]() In this study, blood samples were obtained from well-suppressed ART-experienced HIV-1 patients monitored in Uganda (nā=ā62) or the U.S. ![]() Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with non-B HIV-1 subtypes, which are the predominant viruses seen in low- and middle-income countries (LMIC) in Africa and Asia. ![]()
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